Matrix metalloproteinases :<b>Geeta Chacko</b>, Neurololy India

Matrix metalloproteinases (MMPs) are a family of enzymes that regulate the extracellular matrix environment and whose activity has been implicated in normal and pathological processes. [1],[2] There are 23 MMPs identified in humans and these are upregulated in response to injury and during tumorgenesis. It has been reported that MMP-3, 8, and 12 null mice show increased tumor growth and / or metastases, while MMP-2, 7, 9, 11, and 19 null mice show decreased tumor growth and / or metastases. [3]